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Kefir grains production—An approach for volume optimization of two-stage bioreactor system

Paper ID Volume ID Publish Year Pages File Format Full-Text
4353 222 2008 6 PDF Available
Title
Kefir grains production—An approach for volume optimization of two-stage bioreactor system
Abstract

The main objective of the present study was to design a continuous two-stage bioreactor system for kefir grains production. Based on the experimental data of time-depended kefir grain mass increase and average pH profile during kefir grains batch propagation, parameters of predictive growth and exponential pH models were initially estimated. Afterwards, the non-linear programming (NLP) optimization problem for estimating the optimal volumes of two unequal in series connected continuously stirred tank bioreactors (CSTB) has been developed. The NLP problem is based on criterion of minimal total holding time (MTHT), kefir grain mass balances in CSTB and parameters of the growth and pH models. The results showed that novel kefir grains production plant with two-stage continuous operation, at capacity, qm,KG,pr = 3 kg h−1 and conversion, Xo,2 = 0.980, would primarily require investment in two CSTB with V1 = 5.93 m3 and V2 = 5.62 m3, respectively. Technological and economical authorization for a two-stage continuous bioreactor system was mainly confirmed with a more than five times lower total bioreactor volume compared to one-stage plant.

Keywords
CSTB, continuously stirred tank bioreactor; GAMS, general algebraic modeling system; MTHT, minimal total holding time; NLP, non-linear programmingKefir grains production; Bioreactor design; Modeling; Optimization; Continuous operation mode
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Kefir grains production—An approach for volume optimization of two-stage bioreactor system
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 42, Issue 2, 1 November 2008, Pages 153–158
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us