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Biodegradable Fe-based alloys for use in osteosynthesis: Outcome of an in vivo study after 52 weeks

Paper ID Volume ID Publish Year Pages File Format Full-Text
444 42 2014 8 PDF Available
Title
Biodegradable Fe-based alloys for use in osteosynthesis: Outcome of an in vivo study after 52 weeks
Abstract

This study investigates the degradation performance of three Fe-based materials in a growing rat skeleton over a period of 1 year. Pins of pure Fe and two Fe-based alloys (Fe–10Mn–1Pd and Fe–21Mn–0.7C–1Pd, in wt.%) were implanted transcortically into the femur of 38 Sprague–Dawley rats and inspected after 4, 12, 24 and 52 weeks. The assessment was performed by ex vivo microfocus computed tomography, weight-loss determination, surface analysis of the explanted pins and histological examination. The materials investigated showed signs of degradation; however, the degradation proceeded rather slowly and no significant differences between the materials were detected. We discuss these unexpected findings on the basis of fundamental considerations regarding iron corrosion. Dense layers of degradation products were formed on the implants’ surfaces, and act as barriers against oxygen transport. For the degradation of iron, however, the presence of oxygen is an indispensable prerequisite. Its availability is generally a critical factor in bony tissue and rather limited there, i.e. in the vicinity of our implants. Because of the relatively slow degradation of both pure Fe and the Fe-based alloys, their suitability for bulk temporary implants such as those in osteosynthesis applications appears questionable.

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Keywords
Iron; Iron alloys; Biodegradation; Fracture fixation; μCT
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Biodegradable Fe-based alloys for use in osteosynthesis: Outcome of an in vivo study after 52 weeks
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 10, Issue 7, July 2014, Pages 3346–3353
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us