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An aseptically operatable static solid state bioreactor consisting of two units

Paper ID Volume ID Publish Year Pages File Format Full-Text
4449 226 2008 4 PDF Available
Title
An aseptically operatable static solid state bioreactor consisting of two units
Abstract

A novel, aseptic 100 l packed bed bioreactor consisting of two vessels was developed and tested. One vessel was used for substrate sterilization and the other for cultivation. The sterilized medium was transported by vibration to the cultivation vessel. Even distribution of the inoculum throughout the substrate was achieved by spraying the inoculum on the medium during its transport to the cultivation vessel. Two different mycelial microorganisms were cultivated in the bioreactor: the fungus Phlebiopsis gigantea and the bacterium Streptomyces sp. K61 which are used commercially as biofungicides. The bioreactor was easy to use and the temperature was maintained at an acceptable level. The final spore concentrations obtained in the cultivations were 3.6 × 106 cfu/g for P. gigantea and 4.5 × 109 cfu/g for Streptomyces sp. in the dried media.

Keywords
Batch processing; Biofungicides; Microbial growth; Packed bed bioreactor; Scale-up; Solid state fermentation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 39, Issue 3, 1 May 2008, Pages 594–597
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us