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Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
449 44 2014 13 PDF Available
Title
Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level ☆
Abstract

Fibrinogen is one of the primary components of the coagulation cascade and rapidly forms an insoluble matrix following tissue injury. In addition to its important role in hemostasis, fibrin acts as a scaffold for tissue repair and provides important cues for directing cell phenotype following injury. Because of these properties and the ease of polymerization of the material, fibrin has been widely utilized as a biomaterial for over a century. Modifying the macroscopic properties of fibrin, such as elasticity and porosity, has been somewhat elusive until recently, yet with a molecular-level rational design approach it can now be somewhat easily modified through alterations of molecular interactions key to the protein’s polymerization process. This review outlines the biochemistry of fibrin and discusses methods for modification of molecular interactions and their application to fibrin based biomaterials.

Keywords
Fibrin; Biomaterial design; Fibrin glue; Wound repair; Tissue engineering
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Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 10, Issue 4, April 2014, Pages 1502–1514
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us