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Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
457 44 2014 13 PDF Available
Title
Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications ☆
Abstract

Heparin plays an important role in many biological processes via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties, such as anticoagulant activity, growth factor binding, and antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment.

Keywords
Heparin; Hydrogels; Nanoparticles; Tissue engineering; Drug delivery
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Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 10, Issue 4, April 2014, Pages 1588–1600
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us