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Partitioning of Ciprofloxacin in aqueous two-phase system of poly(ethylene glycol) and sodium sulphate

Paper ID Volume ID Publish Year Pages File Format Full-Text
4573 232 2008 7 PDF Available
Title
Partitioning of Ciprofloxacin in aqueous two-phase system of poly(ethylene glycol) and sodium sulphate
Abstract

Extraction by an aqueous two-phase system is a powerful technique for separation, concentration, and purification of biomolecules and pharmaceutical products. In the present study, the partitioning of Ciprofloxacin in aqueous two-phase system of PEG–Na2SO4–water has been investigated. The influences of temperature, salt concentration, polymer concentration and polymer molecular weight on the partitioning of Ciprofloxacin were studied. The experiments were designed using an orthogonal central composite design (orthogonal CCD) based on 23 full factorial and a second-order model was used to determine the effects of different factors on Ciprofloxacin partitioning. The results of the model indicate that the Ciprofloxacin partitioning is highly dependent on salt concentration. Temperature and PEG concentration have moderate effects on partitioning but PEG molecular weight has no significant effect on the antibiotic partitioning.

Keywords
Aqueous two-phase system; ATPS; Partitioning; Ciprofloxacin; Experimental design
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Partitioning of Ciprofloxacin in aqueous two-phase system of poly(ethylene glycol) and sodium sulphate
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 38, Issue 2, 15 February 2008, Pages 241–247
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us