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Resilin: Protein-based elastomeric biomaterials ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
458 44 2014 11 PDF Available
Title
Resilin: Protein-based elastomeric biomaterials ☆
Abstract

Resilin is an elastomeric protein found in insect cuticles and is remarkable for its high strain, low stiffness, and high resilience. Since the first resilin sequence was identified in Drosophilia melanogaster (fruit fly), researchers have utilized molecular cloning techniques to construct resilin-based proteins for a number of different applications. In addition to exhibiting the superior mechanical properties of resilin, resilin-based proteins are autofluorescent, display self-assembly properties, and undergo phase transitions in response to temperature. These properties have potential application in designing biosensors or environmentally responsive materials for use in tissue engineering or drug delivery. Furthermore, the capability of resilin-based biomaterials has been expanded by designing proteins that include both resilin-based sequences and bioactive domains such as cell-adhesion or matrix metalloproteinase sequences. These new materials maintain the superior mechanical and physical properties of resilin and also have the added benefit of controlling cell response. Because the mechanical and biological properties can be tuned through protein engineering, a wide range of properties can be achieved for tissue engineering applications including muscles, vocal folds, cardiovascular tissues, and cartilage.

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Keywords
Thermal responsiveness; Resilience; Self-assembly; Tissue engineering; Protein engineering
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Resilin: Protein-based elastomeric biomaterials ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 10, Issue 4, April 2014, Pages 1601–1611
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us