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Heterogeneous photocatalysis of moxifloxacin: Identification of degradation products and determination of residual antibacterial activity

Paper ID Volume ID Publish Year Pages File Format Full-Text
46241 46435 2013 9 PDF Available
Title
Heterogeneous photocatalysis of moxifloxacin: Identification of degradation products and determination of residual antibacterial activity
Abstract

•Identification of photocatalytic degradation products of MOX at three pH levels.•Proposal of initial photocatalytic degradation pathway of MOX.•Evaluation of antibacterial activity after photocatalytic reaction at three pH levels.

TiO2-mediated heterogeneous photocatalysis of the fluoroquinolone antibiotic moxifloxacin in water is investigated with respect to both the formation of degradation products and the evaluation of residual antibacterial activity after photocatalytic treatment. High-resolution magnetic sector mass spectrometry coupled to high performance liquid chromatograph is used to determine the accurate mass of the measured degradation products. Eight main photoproducts are identified at both acidic, neutral and alkaline pH. A molecular structure is proposed by using the accurate mass, the double bond equivalent and by taking into account the structural formula of the parent compound. The photocatalytic degradation does not take place at the quinolone core and defluorination was not observed. A general initial photocatalytic pathway for moxifloxacin is proposed. Time profiles of the different degradation products reveal that the solution pH influences their relative abundance during reaction but the observed degradation products show no pH dependency. Residual antibacterial activity of the photocatalytic reaction solutions against Escherichia coli (G−), Staphylococcus carnosus (G+), Streptococcus mutans (G+) and Klebsiella pneumoniae (G−) is evaluated by means of agar diffusion tests. A reduction in antibacterial activity is noticed for all investigated pH levels with a complete inactivation at neutral pH after 12 min of photocatalytic treatment.

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Keywords
Heterogeneous photocatalysis; Fluoroquinolone; Pathway; Degradation products; Antibacterial activity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Applied Catalysis B: Environmental - Volumes 138–139, 17 July 2013, Pages 333–341
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
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Don't Miss Today's Special Offer
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Price after discount Only $4.95
100% Money Back Guarantee
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