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Photocatalytic degradation of olanzapine in aqueous and river waters suspension of titanium dioxide

Paper ID Volume ID Publish Year Pages File Format Full-Text
46359 46438 2012 9 PDF Available
Title
Photocatalytic degradation of olanzapine in aqueous and river waters suspension of titanium dioxide
Abstract

The photostability of olanzapine, recently most commonly used atypical antipsychotic agent, was investigated. Two irradiation sources were applied, namely solar simulated light (E = 250 and 500 W/m2) and monochromatic ultraviolet light (λ = 254 and 366). The olanzapine adsorption on a titanium dioxide surface was confirmed by differential scanning calorimetry and infrared spectroscopy. Kinetic studies were performed on a basis of a spectrophotometric method. Degradation efficiency was assessed by applying high performance liquid chromatography with an ultraviolet detection. HPLC analysis did not show any degradation products. Olanzapine was found to degrade under photocatalytic conditions with the creation of low molecular products. Disappearance of olanzapine from titanium dioxide surface after degradation was confirmed by IR spectra. A simple and promising way to apply the photocatalytic removal of olanzapine in titanium dioxide suspension was presented.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The photostability of olanzapine was investigated. ► Two irradiation sources were applied. ► Olanzapine was found to undergo a complete decomposition. ► A simple and promising way of olanzapine removal from river waters was presented.

Keywords
Heterogeneous photocatalysis; Photodegradation; Titanium dioxide; Olanzapine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Applied Catalysis B: Environmental - Volumes 117–118, 18 May 2012, Pages 96–104
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
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Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us