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Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor

Paper ID Volume ID Publish Year Pages File Format Full-Text
4662 236 2008 8 PDF Available
Title
Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor
Abstract

Centrifugal impeller bioreactor (CIB) was recently developed for shear sensitive biological systems. To better understand its fluid velocity profile, liquid circulation flow, shear stress, and circulation time distribution (CTD), in this study a computational fluid dynamics (CFD) approach was taken to quantitatively assess the effects of major impeller designing and bioreactor operating parameters on those characteristics. Comparison of the simulated velocity profiles near the impeller tip with the experimental measurement results was carried out, and a good agreement was demonstrated. Based on the simulated circulation flow through the draft tube, a new empirical correlation of the circulation flow (QL) with respect to the impeller designing and operating parameters was established. In addition, three distinct circulation cycles were identified and their time distribution was quantified. The above information obtained from the CFD simulation and analysis is helpful to future optimization and scale-up/scale-down of the CIB.

Keywords
CFD; Centrifugal impeller; Velocity profile; Shear force; Fluid circulation; Circulation time distribution
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Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 38, Issue 3, 15 March 2008, Pages 406–413
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us