fulltext.study @t Gmail

Microbial enantioselective reduction of ethyl-2-oxo-4-phenyl-butanoate

Paper ID Volume ID Publish Year Pages File Format Full-Text
4677 237 2006 4 PDF Available
Title
Microbial enantioselective reduction of ethyl-2-oxo-4-phenyl-butanoate
Abstract

Different microorganisms (MOs) were used to carry out the enantioselective reduction of ethyl-2-oxo-4-phenylbutanoate to (S)-(+)-2-hydroxy-4-phenylbutanoate or (R)-(+)-2-hydroxy-4-phenylbutanoate. Commercially available Saccharomyces cerevisiae and Dekera sp. led to over 92% ee of (S)-(+)-2-hydroxy-4-phenylbutanoate. Kluyveromyces marxianus gave the opposite isomer with 32% ee (R). All reactions, except those with Hansenula sp., proceeded to greater than 90% conversion. This the first report on the use of Dekera sp., Hansenula sp. and K. marxianus in the reduction of α-ketoesters.

Keywords
Saccharomyces cerevisiae; Dekera sp.; Hansenula sp.; Kluyveromyces marxianus; Lisinopril; ACE inhibitors
First Page Preview
Microbial enantioselective reduction of ethyl-2-oxo-4-phenyl-butanoate
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 28, Issue 3, 1 March 2006, Pages 299–302
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us