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Comparison of torque method and temperature method for determination of power consumption in disposable shaken bioreactors

Paper ID Volume ID Publish Year Pages File Format Full-Text
4687 238 2007 4 PDF Available
Title
Comparison of torque method and temperature method for determination of power consumption in disposable shaken bioreactors
Abstract

Disposable bioreactors are increasingly used in bioprocess development of animal cell cultures. However, the engineering parameters of the present disposable bioreactors are very difficult to characterise. Characterisation of any bioreactor is important to evaluate the suitability of operating conditions and absolutely necessary for successful scale-up. In this research work, an attempt is made to validate a characterisation method which is simple and can be used for any given volume of disposable bioreactors larger than 2 L. Two evaluation methods, namely the temperature method and the well established torque method were used for determination of power consumption in 2 L and 20 L disposable shaken bioreactors. The trend of the values of power consumption was shown with respect to shaking frequency and filling volume. Results indicate that quite reasonable values of power consumption can be obtained by the temperature method and the torque method, which are in good agreement with each other (error <30%).

Keywords
Bioprocess development; Disposable; Shaken bioreactor; Characterisation; Power consumption; Torque; Temperature; Validation
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Comparison of torque method and temperature method for determination of power consumption in disposable shaken bioreactors
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 34, Issue 3, June 2007, Pages 224–227
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us