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Kinetic modeling using S-systems and lin-log approaches

Paper ID Volume ID Publish Year Pages File Format Full-Text
4758 243 2007 10 PDF Available
Title
Kinetic modeling using S-systems and lin-log approaches
Abstract

We analyze the growth dynamics and production of an industrially interesting amino acid in a recombinant Escherichia coli strain, using in parallel two alternative modeling frameworks, namely S-systems and lin-log models. These models have identical steady-state solutions, but differ in their representation of transients. The models were parameterized with data from two bioprocesses that differed in their initial culture concentrations and then used to predict responses under yet a different initial culture regimen. Among the S-system models, several alternatives representing slightly different pathway structures, were tested. All were found to be capable of capturing the dynamics of all variables in the test systems and also of predicting the dynamic responses under new conditions. The lin-log models also captured the dynamics, but not as well as the S-system models. A probable reason for the inferior performance of lin-log models is their intrinsic property of not representing situations well where variable concentrations are moderately small.

Keywords
Parameter estimation; Biochemical Systems Theory; Dynamic modeling; Amino acid; Kinetic parameters; Fermentation; Bioprocess control
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 33, Issue 3, March 2007, Pages 238–247
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us