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Maximization of metabolite in fed-batch cultures: Sufficient conditions for singular arc and optimal feed rate profiles

Paper ID Volume ID Publish Year Pages File Format Full-Text
4788 245 2007 13 PDF Available
Title
Maximization of metabolite in fed-batch cultures: Sufficient conditions for singular arc and optimal feed rate profiles
Abstract

Fed-batch fermentation for maximization of metabolite production at a final time is normally a singular control problem. The singular optimal feed rate strategy depends on relative position of peaks in the specific rates of cell growth μ, substrate consumption σ and product formation π. Regions in which singular feed rates exist are identified and variation of substrate concentration in the singular region is elucidated. Sufficient conditions for the existence of a singular arc are developed, which can be incorporated into an efficient and stable computational scheme to obtain the optimal feed rate profiles.

Keywords
Fed-batch culture; Control; Optimization; Modeling; Singular arc; Sufficient conditions
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Maximization of metabolite in fed-batch cultures: Sufficient conditions for singular arc and optimal feed rate profiles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 37, Issue 1, 15 October 2007, Pages 62–74
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us