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Development of adaptive modeling techniques to describe the temperature-dependent kinetics of biotechnological processes

Paper ID Volume ID Publish Year Pages File Format Full-Text
4807 246 2007 10 PDF Available
Title
Development of adaptive modeling techniques to describe the temperature-dependent kinetics of biotechnological processes
Abstract

Bioprocesses are quite difficult and expensive to model, since their operation involves microbial growth under constantly changing conditions, with impact on process kinetics and performance. Hence, there is a need and incentive for the improvement of methods for rapid development of simple, though realistic, mathematical models. In this work the modeling of biotechnological processes is studied with focus on developing methodologies that can be used whenever a re-estimation of parameters is necessary. The ethanol fermentation process is used as a case study. The performance of a hybrid neural model and a balance based model, both considering the effect of temperature on the kinetics, are evaluated not only by their accuracy in describing experimental data, but also by the difficulties involved in the adaptation of their parameters. Experiments are performed to develop the two models and further experiments (using sugar cane molasses from a different harvest and a different production medium) validate the methodologies for re-estimation of kinetic parameters.

Keywords
Bioreactors; Modeling; Optimization; Parameter estimation; Temperature effect; Artificial intelligence
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Development of adaptive modeling techniques to describe the temperature-dependent kinetics of biotechnological processes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 36, Issue 2, 15 September 2007, Pages 157–166
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us