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Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins

Paper ID Volume ID Publish Year Pages File Format Full-Text
484 45 2012 8 PDF Available
Title
Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins
Abstract

Photo-crosslinked networks were prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone. Two model proteins, lysozyme and albumin, were incorporated into the network films as solid particles and their release behavior was studied. By varying the NVP content and macromer molecular weight the degradation behavior and protein release profiles of the prepared networks could be tuned. The more hydrophilic and less densely crosslinked networks released albumin and lysozyme at a faster rate. Although active lysozyme was released from the networks over the complete release period, lysozyme release was often incomplete. This was most likely caused by electrostatic and/or hydrophobic interactions between the protein and the degrading polymer network.

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Keywords
Drug delivery systems; Networks; Photo-polymerization; Proteins; Fumarate
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Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 10, October 2012, Pages 3652–3659
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us