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Electrospun synthetic human elastin:collagen composite scaffolds for dermal tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
491 45 2012 9 PDF Available
Title
Electrospun synthetic human elastin:collagen composite scaffolds for dermal tissue engineering
Abstract

We present an electrospun synthetic human elastin:collagen composite scaffold aimed at dermal tissue engineering. The panel of electrospun human tropoelastin and ovine type I collagen blends comprised 80% tropoelastin + 20% collagen, 60% tropoelastin + 40% collagen and 50% tropoelastin + 50% collagen. Electrospinning efficiency decreased with increasing collagen content under the conditions used. Physical and mechanical characterization encompassed fiber morphology, porosity, pore size and modulus, which were prioritized to identify the optimal candidate for dermal tissue regeneration. Scaffolds containing 80% tropoelastin and 20% collagen (80T20C) were selected on this basis for further cell interaction and animal implantation studies. 80T20C enhanced proliferation and migration rates of dermal fibroblasts in vitro and were well tolerated in a mouse subcutaneous implantation study where they persisted over 6 weeks. The 80T20C scaffolds supported fibroblast infiltration, de novo collagen deposition and new capillary formation.

Keywords
Synthetic human elastin; Tropoelastin; Collagen; Dermal substitute; Electrospinning
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Electrospun synthetic human elastin:collagen composite scaffolds for dermal tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 10, October 2012, Pages 3714–3722
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us