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Sc(OTf)3-catalyzed three-component cascade reaction: One-pot synthesis of substituted 3-oxoisoindoline-1-carbonitrile derivatives

Paper ID Volume ID Publish Year Pages File Format Full-Text
49269 46730 2016 3 PDF Available
Title
Sc(OTf)3-catalyzed three-component cascade reaction: One-pot synthesis of substituted 3-oxoisoindoline-1-carbonitrile derivatives
Abstract

•A facile method for the synthesis of isoindolinones was developed.•A broad scope of amine substrates was suitable for this process.•Good to excellent yields (up to 97%) were achieved in most cases.

A facile and efficient approach for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives has been developed, with a Sc(OTf)3-catalyzed three-component Strecker/Lactamization cascade reaction involving methyl 2-formylbenzoate, TMSCN and amines in ethanol at room temperature. Good to excellent yields for a broad scope of amine substrates were achieved.

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Keywords
Isoindolinones; Cascade reaction; Amines; Sc(OTf)3
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Sc(OTf)3-catalyzed three-component cascade reaction: One-pot synthesis of substituted 3-oxoisoindoline-1-carbonitrile derivatives
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 74, 10 January 2016, Pages 119–121
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
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Price was $35.95
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