fulltext.study @t Gmail

Asymmetric transfer hydrogenation of ketones by N,N-containing quinazoline-based ruthenium(II) complexes

Paper ID Volume ID Publish Year Pages File Format Full-Text
49270 46730 2016 4 PDF Available
Title
Asymmetric transfer hydrogenation of ketones by N,N-containing quinazoline-based ruthenium(II) complexes
Abstract

•This is the first example of chiral amino Quinazoline-based ruthenium complex.•The related complexes were used in asymmetric transfer hydrogenation reaction.•The catalytic activity of these complexes were compared according to the chirality environment•These complexes are advantageous as they are air stable and derived from amino acids.

The novel set of quinazoline-based chiral ligands was synthesized starting from optically pure amino acids. Coordination with RuCl2(PPh3)dppb gave ruthenium(II) N-heterocyclic complexes 4b–d. The structure of complex 4b was fully illuminated by X-ray crystallography. The steric environment of these chiral ruthenium complexes 4b–d was evaluated in asymmetric transfer hydrogenation (ATH) of prochiral ketones in the presence of NaOiPr by using 2-propanol as the hydrogen source and solvent. The resultant catalytic system can achieve very good enantioselectivities (up to 91%) and high yields (up to 99%).

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Quinazoline; N,N based ligand; Ruthenium; Asymmetric transfer hydrogenation
First Page Preview
Asymmetric transfer hydrogenation of ketones by N,N-containing quinazoline-based ruthenium(II) complexes
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 74, 10 January 2016, Pages 122–125
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis