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A facile, efficacious and reusable Sm2O3/ZrO2 catalyst for the novel synthesis of functionalized 1,4-dihydropyridine derivatives

Paper ID Volume ID Publish Year Pages File Format Full-Text
49276 46731 2016 5 PDF Available
Title
A facile, efficacious and reusable Sm2O3/ZrO2 catalyst for the novel synthesis of functionalized 1,4-dihydropyridine derivatives
Abstract

•One-pot four-component novel synthesis of eleven functionalized pyridines•Excellent yields (87 to 96%) at RT in short reaction times (< 20 min)•Sm2O3/ZrO2 as a superb heterogeneous catalyst•Easy recovery and reusability of catalyst (7 runs)•Green solvent/ethanol and cost effective reagents

An efficient four component/one-pot protocol was developed for synthesis of novel functionalized 1,4-dihydropyridines at room temperature by a reaction of malononitrile, substituted aldehydes, dimethylacetylenedicarboxylate and 4-fluoroaniline in ethanol and using Sm2O3/ZrO2 as catalyst. All reactions were completed in < 20 min. The structures of all the new compounds were confirmed by different spectral analyses. The catalyst, Sm2O3/ZrO2 was synthesized and characterized by various techniques including powder X-ray diffraction, N2 adsorption/desorption, scanning electron microscopy, and transmission electron microscopy analysis. The key advantages of this process are good to high yields (87 to 96%), short reaction times, easy work-up, reusability and no chromatographic purification.

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Keywords
Green synthesis; Functionalized pyridines; Multicomponent reactions; Heterogeneous catalyst; Recyclability; Sm2O3/ZrO2; Mixed oxide catalyst
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A facile, efficacious and reusable Sm2O3/ZrO2 catalyst for the novel synthesis of functionalized 1,4-dihydropyridine derivatives
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 79, 5 April 2016, Pages 21–25
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us