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Efficient enzymatic synthesis of ampicillin using mutant Penicillin G acylase with bio-based solvent glycerol

Paper ID Volume ID Publish Year Pages File Format Full-Text
49278 46731 2016 4 PDF Available
Title
Efficient enzymatic synthesis of ampicillin using mutant Penicillin G acylase with bio-based solvent glycerol
Abstract

•Bio-based solvent glycerol was used for ampicillin synthesis.•An ampicillin yield of 93.5% was achieved at low acyl donor/nucleophile ratio (1.05:1).•1.12 mol acyl donor D-PGME was required to produce 1 mol ampicillin.

To fulfill the industry demand of ampicillin enzymatic synthesis, immobilized mutant Penicillin G acylase and bio-based solvent glycerol were employed at high substrate concentration and low acyl donor/nucleophile ratio. After process optimization, good yield and low operation costs were achieved.

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Keywords
Penicillin G acylase; Antibiotic; Biocatalysis; Bio-based solvent
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Efficient enzymatic synthesis of ampicillin using mutant Penicillin G acylase with bio-based solvent glycerol
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 79, 5 April 2016, Pages 31–34
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us