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Palladium-catalyzed efficient Suzuki–Miyaura reaction of potassium aryltrifluoroborates in water

Paper ID Volume ID Publish Year Pages File Format Full-Text
49356 46740 2015 5 PDF Available
Title
Palladium-catalyzed efficient Suzuki–Miyaura reaction of potassium aryltrifluoroborates in water
Abstract

•Suzuki–Miyaura reaction of potassium aryltrifluoroborates in pure water•(i-Pr)2NH promotes the cross-coupling efficiently.•This protocol provides a gram scale preparation of 2-cyano-4′-methylbiphenyl.•The products could be isolated by simple filtration and recrystallization.

An efficient and environment-friendly protocol has been developed for the palladium-catalyzed Suzuki–Miyaura reaction of potassium aryltrifluoroborates with (hetero)aryl halides in water without any additive. This method allows the preparation of a variety of biaryls and heterobiaryls in excellent yields. In addition, the cross-coupling product can be isolated in good yields and high purity by simple filtration and recrystallization as the reaction was performed on gram scale.

Graphical abstractAn efficient and environment-friendly protocol has been developed for the palladium-catalyzed Suzuki–Miyaura reaction of potassium aryltrifluoroborates and (hetero)aryl halides in water without any additives.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Palladium; Suzuki–Miyaura reaction; Aryltrifluoroborates; Water; Gram scale
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Palladium-catalyzed efficient Suzuki–Miyaura reaction of potassium aryltrifluoroborates in water
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 69, 5 September 2015, Pages 81–85
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us