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Heterogeneous asymmetric hydrogenation of aromatic ketones enhanced by silanols on highly monodispersed silica spheres

Paper ID Volume ID Publish Year Pages File Format Full-Text
49574 46755 2014 4 PDF Available
Title
Heterogeneous asymmetric hydrogenation of aromatic ketones enhanced by silanols on highly monodispersed silica spheres
Abstract

•The asymmetric hydrogenation of aromatic ketones was enhanced by silanols.•> 99.9% ee and > 99% conversion were obtained.•A proposed H-bonding was speculated and proved by FTIR.•With the silanols increasing, the activity of hydrogenation increased.

A triphenylphosphine-stabilized Ir/SiO2 catalyst modified by a chiral diamine was synthesized with four silica spheres as support for the asymmetric hydrogenation of aromatic ketones. The H-bond between substrate and silanols and the interaction between substrate and modifier commonly affected the steric configuration of asymmetric hydrogenation of aromatic ketones. With the silanols increasing, the activity of asymmetric hydrogenation significantly increased. This is the first report of heterogeneous asymmetric hydrogenation of aromatic ketones enhanced by silanols on highly monodispersed silica spheres with > 99.9% ee and > 99% conversion.

Graphical abstractThis is the first report of the heterogeneous asymmetric hydrogenation of simple aromatic ketones enhanced by silanols. With the silanols increasing, the enantioselectivity and activity increased. > 99.9% ee and > 99% conversion were obtained.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Heterogeneous; Asymmetric hydrogenation; Silanols; Iridium; KetonesGEFJOJANHHIEKG-UHFFFAOYSA-N
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Heterogeneous asymmetric hydrogenation of aromatic ketones enhanced by silanols on highly monodispersed silica spheres
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 54, 5 September 2014, Pages 27–30
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
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Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us