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S-system approach to modeling recombinant Escherichia coli growth by hybrid differential evolution with data collocation

Paper ID Volume ID Publish Year Pages File Format Full-Text
4971 265 2006 7 PDF Available
Title
S-system approach to modeling recombinant Escherichia coli growth by hybrid differential evolution with data collocation
Abstract

In this study, we have established a suitable model to describe the dynamic characteristic of an aspartase-overproducing Escherichia coli strain. A traditional Monod model and power-law models are respectively applied to describe the dynamic behaviors. When the model structure was selected, the parameter values of the model should be determined by the global/local optimization method. There are two major challenges, numerical integration for differential equations and finding global parameter values. In this study, we introduce hybrid differential evolution, which is a variant of genetic algorithms, to avoid obtaining a premature solution. In addition, we apply a modified collocation method to avoid numerical integration. The Monod's model could only predict the growth characteristic of the recombinant E. coli, qualitatively. The S-system representation could suit for constructing the model structure of the microbial growth.

Keywords
Modeling; Biokinetics; Growth kinetics; Kinetic parameters; Fermentation; Parameter estimation
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S-system approach to modeling recombinant Escherichia coli growth by hybrid differential evolution with data collocation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 28, Issue 1, February 2006, Pages 10–16
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us