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Zn-VCO3 hydrotalcite: A highly efficient and reusable heterogeneous catalyst for the Hantzsch dihydropyridine reaction

Paper ID Volume ID Publish Year Pages File Format Full-Text
49759 46764 2014 5 PDF Available
Title
Zn-VCO3 hydrotalcite: A highly efficient and reusable heterogeneous catalyst for the Hantzsch dihydropyridine reaction
Abstract

•Eco-friendly and cost-effective method for Hantzsch dihydropyridine reaction.•Efficient protocol using Hydrotalcite as a heterogeneous catalyst.•One-pot synthesis with good yields.

The Zn-VCO3 hydrotalcite was found to be an excellent solid catalyst for the one-pot synthesis of triphenylpyridine-3,5-dicarboxamide via Hantzsch reaction of acetoacetanilide, ammonium hydroxide and various aromatic aldehydes. The combinatorial syntheses were achieved for the first time using hydrotalcite as a heterogeneous catalyst. The catalyst was active for the Hantzsch reaction in water at 60 °C. The products were isolated in good yields (85–93%) with short reaction times (2–3 h). The resulting substituted dihydropyridines were characterized and confirmed by 1H and 13C NMR, FTIR, and HRMS spectral data and the solid catalyst was characterized by XRD, BET, SEM and TEM. The newly synthesized heterogeneous solid catalyst offers simple means for recovery and the isolated catalyst was reused for five rounds for the synthesis of compound 4a, without significant loss of catalytic activity. For all the other reactions carried out with the recycled catalyst, results were similar to with the fresh catalyst.

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Keywords
Multicomponent reaction; One-pot synthesis; Heterogeneous catalysis; Hantzsch reaction; Hydrotalcite; Green chemistry
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Zn-VCO3 hydrotalcite: A highly efficient and reusable heterogeneous catalyst for the Hantzsch dihydropyridine reaction
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 45, 5 February 2014, Pages 148–152
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us