fulltext.study @t Gmail

Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase

Paper ID Volume ID Publish Year Pages File Format Full-Text
49887 46770 2015 4 PDF Available
Title
Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase
Abstract

•A green and efficient enzymatic method for Knoevenagel condensation was developed.•Products were obtained in good to excellent yields in short reaction times.•Only Z-isomers were obtained under our reaction conditions.

A screening of using different lipases to catalyze the Knoevenagel reaction was realized, and lipase lipoprotein (LPL) from Aspergillus niger showed the best catalytic performance. The reaction conditions including solvent, enzyme loading, and temperature were screened to improve the reaction efficiency. Various kinds of substrates were investigated, and almost all the target products were obtained in good to excellent yields (76–98%) with Z configuration exclusively. This procedure provides a novel, green and efficient method for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds.

Keywords
Lipases; Knoevenagel condensation; Aromatic aldehydes; Active methylene compounds
First Page Preview
Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 64, 5 April 2015, Pages 101–104
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us