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Novel route for the synthesis of 8-oxa-3-azabicyclo[3.2.1]octane: One-pot aminocyclization of 2,5-tetrahydrofurandimethanol catalyzed by Pt/NiCuAlOx

Paper ID Volume ID Publish Year Pages File Format Full-Text
49931 46773 2015 5 PDF Available
Title
Novel route for the synthesis of 8-oxa-3-azabicyclo[3.2.1]octane: One-pot aminocyclization of 2,5-tetrahydrofurandimethanol catalyzed by Pt/NiCuAlOx
Abstract

•8-oxa-3-azabicyclo[3.2.1]octane was synthesized from THDMF.•Pt/NiCuAlOx is an active catalyst for aminocyclization of THDMF.•The one-pot synthesis of 8-oxa-3-azabicyclo[3.2.1]octane was realized.

2,5-Tetrahydrofurandimethanol (THFDM) was selectively transformed into 8-oxa-3-azabicyclo[3.2.1] octane (OABCO), a valuable building block for the synthesis of bioactive molecules, via one-pot aminocyclization with ammonia catalyzed by Pt/NiCuAlOx. Under optimized conditions (200 °C, 6–16 h, 0.5 MPa hydrogen, 0.4 MPa ammonia), the OABCO yield reached 58% with 100% THFDM conversion.

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Keywords
YCZZQSFWHFBKMU-UHFFFAOYSA-N; POOPWPIOIMBTOH-UHFFFAOYSA-NTetrahydrofurandimethanol; 8-Oxa-3-azabicyclo[3.2.1]octane; Ammonia; Amination; Biomass
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Novel route for the synthesis of 8-oxa-3-azabicyclo[3.2.1]octane: One-pot aminocyclization of 2,5-tetrahydrofurandimethanol catalyzed by Pt/NiCuAlOx
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 58, 5 January 2015, Pages 195–199
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us