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Chitosan: An efficient biodegradable and recyclable green catalyst for one-pot synthesis of 3,4-dihydropyrimidinones of curcumin in aqueous media

Paper ID Volume ID Publish Year Pages File Format Full-Text
49965 46775 2012 6 PDF Available
Title
Chitosan: An efficient biodegradable and recyclable green catalyst for one-pot synthesis of 3,4-dihydropyrimidinones of curcumin in aqueous media
Abstract

An efficient procedure for the synthesis of curcumin 3,4-dihydropyrimidinones has been developed by simple one-pot condensation of curcumin, aromatic aldehydes and urea/thiourea in the presence of commercially available chitosan in 2% acetic acid in aqueous media at 60 °C for 80–90 min. In the reaction, curcumin: a potential biologically active molecule has been used as a component of multi-component synthesis using chitosan as an efficient biodegradable and recyclable green catalyst. The resultant product curcumin 3,4-dihydropyrimidinone is formed in excellent yield (97%). The chitosan catalyst can be reused for without loss of catalytic activity.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Chitosan used in the present procedure is biodegradable and reusable catalyst. ► No significant loss of catalytic activity when tested up to five catalytic cycles. ► The catalytic reaction was carried out in aqueous media. ► Yield of the desired product is excellent in the present synthesis.

Keywords
Curcumin; Chitosan; Biodegradable catalyst; Curcumin 3,4-dihydropyrimidinone; Multi-component reaction
First Page Preview
Chitosan: An efficient biodegradable and recyclable green catalyst for one-pot synthesis of 3,4-dihydropyrimidinones of curcumin in aqueous media
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 27, 5 October 2012, Pages 38–43
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis