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Bio-compatible eutectic mixture for multi-component synthesis: A valuable acidic catalyst for synthesis of novel 2,3-dihydroquinazolin-4(1H)-one derivatives

Paper ID Volume ID Publish Year Pages File Format Full-Text
49994 46775 2012 5 PDF Available
Title
Bio-compatible eutectic mixture for multi-component synthesis: A valuable acidic catalyst for synthesis of novel 2,3-dihydroquinazolin-4(1H)-one derivatives
Abstract

Novel derivatives of quinazolin-4(1H)-one derivatives were effectively synthesized via one-pot multi-component reaction of isatoic anhydride, aldehyde and aromatic amines using acidic catalyst in methanol. The catalyst, being a deep eutectic mixture of choline chloride and malonic acid, gave better results than several reported catalysts. Moreover, such eutectic mixtures are cost-effective, recyclable, non-toxic and bio-degradable. The methodology was successfully used for incorporating significant phenyl and heterocyclic substitutions at 2,3-positions of quinazolinone core. In addition, studies related to catalyst screening, substrate variation, recyclability and plausible mechanism of reaction are also described.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► First report on catalytic use of organic acid based eutectic in one-pot synthesis. ► Catalyst easily derived from choline chloride:malonic acid with 100% atom economy. ► Excellent yields of novel quinazolinone derivatives with varied substitutions. ► The method avoids multi-step synthesis, expensive catalysts and harsh conditions. ► Acid catalyst used is bio-degradable, recyclable, non-toxic and cost-effective.

Keywords
Quinazolinone; Multi-component reaction; Deep eutectic solvent; Choline chloride; Malonic acid
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Bio-compatible eutectic mixture for multi-component synthesis: A valuable acidic catalyst for synthesis of novel 2,3-dihydroquinazolin-4(1H)-one derivatives
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 27, 5 October 2012, Pages 179–183
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us