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Lipase-catalyzed kinetic resolution of 3-phenyloxazolidin-2-one derivatives: Cascade O- and N-alkoxycarbonylations

Paper ID Volume ID Publish Year Pages File Format Full-Text
50109 46780 2016 5 PDF Available
Title
Lipase-catalyzed kinetic resolution of 3-phenyloxazolidin-2-one derivatives: Cascade O- and N-alkoxycarbonylations
Abstract

•A lipase-catalyzed, cascade kinetic resolution protocol has been established.•Enantiopure 3-phenyloxazolidin-2-one derivatives have been synthesized.•Candida antarctica Lipase B showed high catalytic activity and stereoselectivity.

A lipase-catalyzed, cascade kinetic resolution protocol has been established for the synthesis of 3-phenyloxazolidin-2-one derivatives with up to excellent enantioselectivities (95% ee). Candida antarctica lipase B showed high catalytic activity and stereoselectivity in sequential O- and N-alkoxycarbonylation processes.

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Keywords
Oxazolidinone; Kinetic resolution; Asymmetric, synthesis; Candida antarctica lipase B; Cascade alkoxycarbonylation
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Lipase-catalyzed kinetic resolution of 3-phenyloxazolidin-2-one derivatives: Cascade O- and N-alkoxycarbonylations
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 82, 5 July 2016, Pages 11–15
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
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