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Usefulness of flow focusing technology for producing subsieve-size cell enclosing capsules: Application for agarose capsules production

Paper ID Volume ID Publish Year Pages File Format Full-Text
5013 269 2006 4 PDF Available
Title
Usefulness of flow focusing technology for producing subsieve-size cell enclosing capsules: Application for agarose capsules production
Abstract

Flow focusing technology is known to be advantageous for micro- and nanoparticle production. We investigated the applicability of this technology to produce subsieve-size mammalian cell-enclosing capsules of less than 100 μm in diameter. Subsieve-size capsules with a narrow size distribution were obtained via droplets breakup in a water-immiscible co-flowing liquid flow by a flow focusing process. Compared with the production process of non-flow focusing, the capsules could be prepared with less consumption of the water-immiscible fluid of liquid paraffin. No harmful effects resulting from the flow focusing process on the cells enclosed in the capsules were detected in this study. The undamaged percentage of the cells immediately after the enclosing process was 96.6 ± 1.8%, and the cells enclosed in subsieve-size agarose capsules showed mitochondrial activity for over 3 weeks. These results showed that flow focusing is an effective process for producing cell-enclosing subsieve-size capsules.

Keywords
Biomedical; Animal cell culture; Immobilisation; Immobilised cells; Subsieve-size capsules; Cell therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 30, Issue 2, 1 June 2006, Pages 218–221
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us