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1,4-Michael additions of cyclic-β-ketoesters catalyzed by DNA in aqueous media

Paper ID Volume ID Publish Year Pages File Format Full-Text
50247 46786 2014 5 PDF Available
Title
1,4-Michael additions of cyclic-β-ketoesters catalyzed by DNA in aqueous media
Abstract

•1,4-Michael addition under st-DNA catalysis•The catalyst can be recovered and reused for further catalytic cycles.•GMP or ethyl guanine shows a similar catalytic efficiency than DNA.

In this work, we describe the 1,4-Michael addition of the 1,3-dicarbonyl compounds to activated ethylenes under st-DNA catalysis in water. The reaction of the β-ketoester 4 with nitroolefins and conjugated carbonyls proceeds quite well, whereas other less activated ethylenes exhibit low or null reactivity. The catalyst can be recovered and reused for several catalytic cycles without significantly diminishing its efficiency. These reactions are similarly catalyzed by GMP, methyl-adenine and ethyl guanine, which suggests that the catalytic activity of st-DNA could be associated to the basic nature of their nucleotides' integrants.

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Keywords
Catalysis; DNA; 1,4-Michael-addition; Aqueous medium
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1,4-Michael additions of cyclic-β-ketoesters catalyzed by DNA in aqueous media
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 44, 10 January 2014, Pages 10–14
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
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Price was $35.95
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