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Fast condensation of cyclohexanone with 2-aminobenzonitrile at room temperature catalysed by an N-heterocyclic carbene

Paper ID Volume ID Publish Year Pages File Format Full-Text
50329 46790 2013 4 PDF Available
Title
Fast condensation of cyclohexanone with 2-aminobenzonitrile at room temperature catalysed by an N-heterocyclic carbene
Abstract

A fast condensation of cyclohexanone with 2-aminobenzonitrile catalysed by N-heterocyclic carbene 1,3-dipropylimidazole-2-ylidene (NHC-PPIm) at room temperature was discovered. NHC-PPIm was prepared via concentration of a 1,3-dipropylimidazolium hydroxide aqueous solution and showed excellent catalytic activity in the condensation reaction for the synthesis of quinazolinone. A possible catalytic mechanism was proposed based on the umpolung of cyclohexanone.

► Synthesis of quinazolinone via condensation of cyclohexanone with 2-aminobenzonitrile. ► An NHC was produced via concentration of a [PPIm][OH] aqueous solution. ► The NHC showed high catalytic activity in the condensation reaction. ► A possible catalytic mechanism was proposed based on the umpolung of cyclohexanone.

Keywords
N-heterocyclic carbene; Quinazolinone; Condensation; Cyclohexanone; 2-Aminobenzonitrile
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Fast condensation of cyclohexanone with 2-aminobenzonitrile at room temperature catalysed by an N-heterocyclic carbene
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 32, 5 February 2013, Pages 1–4
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
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Price was $35.95
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