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Synthesis of tetrahydro-4H-indol-4-one derivatives catalyzed by carbonaceous material

Paper ID Volume ID Publish Year Pages File Format Full-Text
50471 46796 2015 4 PDF Available
Title
Synthesis of tetrahydro-4H-indol-4-one derivatives catalyzed by carbonaceous material
Abstract

•A novel, mild, and environ friendly, one pot synthetic protocol was developed.•The carbonaceous material is first used in domino reaction of nitrostyrene.•The catalyst is reusable and gives high conversions.•The domino reaction follows the acid-catalyzed mechanism.

An efficient, high yielding method has been developed for the synthesis of diversity tetrahydro-4H-indol-4-one derivatives via a three component, one pot domino reaction from cyclohexane-1,3-diones, amines and nitrostyrenes using carbon functionalized with sulfonic acid group carbonaceous material as catalyst for the first time. The reaction was carried out in water, affording good to excellent yields in short time. The advantages of atom and step economy, green, and scope make this reaction a powerful tool for assembling heterocyclic scaffolds of general chemical and biomedical interest.

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Keywords
Synthesis; Water; Tetrahydro-4H-indol-4-one derivatives; Carbonaceous material; Multi-component reaction
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 62, 5 March 2015, Pages 6–9
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
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Price was $35.95
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