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Sequential oxidation and condensation of alcohols to benzimidazoles/benzodiazepines by MoO3–SiO2 as a heterogeneous bifunctional catalyst

Paper ID Volume ID Publish Year Pages File Format Full-Text
50623 46805 2010 6 PDF Available
Title
Sequential oxidation and condensation of alcohols to benzimidazoles/benzodiazepines by MoO3–SiO2 as a heterogeneous bifunctional catalyst
Abstract

Sequential oxidation of alcohols to their corresponding aldehydes/ketones using H2O2 as a green oxidant and its further condensation with diamines to yield benzimidazoles/benzodiazepines with minimum side product formation under mild reaction conditions has been described. MoO3–SiO2 is explored as a heterogeneous bifunctional catalyst for both oxidation as well as condensation reaction thus making it a versatile catalyst. The prepared catalysts were characterized using FT-IR, Raman spectroscopy, XRD, SEM and NH3-TPD to study its surface properties. MoO3–SiO2 shows good catalytic activity and reusability for both the reaction systems giving high yields of the desired products.

Graphical AbstractSequential oxidation of alcohols to their corresponding aldehydes/ketones using H2O2 as a green oxidant and its further condensation with diamines to yield benzimidazoles/benzodiazepines with minimum side product formation under mild reaction conditions has been described.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights►Benzimidazole and benzodiazepines structural motifs have attracted much interest in diverse areas of medicinal chemistry as these heterocycles show various pharmacological activities. ►MoO3–SiO2 is reported as a heterogeneous bifunctional catalyst for sequential oxidation of alcohols to their corresponding aldehydes/ketones and its sequential condensation with OPDA to yield benzimidazoles/benzodiazepines with minimum side product formation under mild reaction conditions. ►Initial step of oxidation of alcohols to their corresponding aldehydes/ketones is carried out using an environmentally benign oxidant H2O2. ►The catalyst was characterized by various analytical techniques such as FT-IR, Raman spectroscopy, XRD, SEM and NH3-TPD to check its surface properties. ►Effects of various parameters such as influence of MoO3–SiO2 with different Mo loading, solvent and catalyst concentration were investigated. ►The catalytic system offers high yields of the desired benzimidazoles/benzodiazepines within short reaction time. ►The catalyst afforded excellent reusability for four cycles without any significant loss in catalytic activity. ►Considering all the above merits, this report is an important supplement to the current methods and may be useful for the wider readership of Catalysis Communications.

Keywords
Sequential; Bifunctional; Oxidation; Condensation; Benimidazole; Benzodiazepine
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Sequential oxidation and condensation of alcohols to benzimidazoles/benzodiazepines by MoO3–SiO2 as a heterogeneous bifunctional catalyst
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 11, Issue 15, 25 September 2010, Pages 1205–1210
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us