Durability enhancement of chirally modified metallic nickel catalysts for enantioselective hydrogenation
Metallic Ni catalysts co-modified with (R,R)-tartaric acid and NaBr showed high enantioselectivity and durability upon hydrogenation of methyl acetoacetate to give methyl 3-hydroxybutyrate. The chirally modified catalyst prepared from 3-μm Ni powder was highly robust to maintain the hydrogenation activity and enantiodifferentiating ability for ca. 3 months under dry condition, which enables long-term storage and hence facilitates commercial distribution and industrial application.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Metallic 3-μm nickel powder catalyst modified with (R,R)-tartaric acid and NaBr. ► Modified catalyst afforded up to 84% ee in the hydrogenation of methyl acetoacetate. ► The dried catalyst was robust and kept the high enantioselectivity for 84 days.
Journal: Catalysis Communications - Volume 15, Issue 1, 15 November 2011, Pages 15–17