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Efficient enzymatic kinetic resolution of 2-heptylamine with a highly active acyl donor

Paper ID Volume ID Publish Year Pages File Format Full-Text
50874 46819 2010 5 PDF Available
Title
Efficient enzymatic kinetic resolution of 2-heptylamine with a highly active acyl donor
Abstract

Novozyme435 facilitated kinetic resolution of 2-heptylamine was here presented. Methyl methoxyacetate was used as acyl donor. A survey of influencing factors including hydrogen bonding effect, solvent effect, steric effect, temperature and the amount of acyl donor were investigated in detail. At the optimum conditions, the enantiomeric separation was successfully obtained within 8 h at 20 °C, and gave high conversion and optical purity of (R)-2-heptylamine, 48.9% and over 99% respectively. The immobilized lipase B was found to be suitable for the enantiomeric separation of aliphatic amines with good recyclability.

Keywords
Enzymatic kinetic resolution; Novozyme435; 2-Heptylamine; Methyl methoxyacetate
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Efficient enzymatic kinetic resolution of 2-heptylamine with a highly active acyl donor
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 11, Issue 11, 10 June 2010, Pages 987–991
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us