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Highly regio- and chemoselective silylation of diethyl α-hydroxyphosphonates, alcohols and phenols in the presence of solid TiCl3(OTf) as a catalyst with hexamethyldisilazane (HMDS) at room temperature in the absence of solvent

Paper ID Volume ID Publish Year Pages File Format Full-Text
51315 46838 2009 4 PDF Available
Title
Highly regio- and chemoselective silylation of diethyl α-hydroxyphosphonates, alcohols and phenols in the presence of solid TiCl3(OTf) as a catalyst with hexamethyldisilazane (HMDS) at room temperature in the absence of solvent
Abstract

Solid trichlorotitanium(IV) trifluoromethanesulfonate [TiCl3(OTf)] is an easily prepared compound from the reaction of TiCl4 with trifluoromethanesulfonic acid. This solid Ti(IV) based compound is used as a catalyst for highly efficient silylation of diethyl α-hydroxyphosphonates, alcohols and phenols with hexamethyldisilazane (HMDS) at room temperature under solvent-free conditions. Chemo- and regioselectivity for masking different hydroxyl functional groups were observed in the presence of this catalyst.

Keywords
Hexamethyldisilazane; α-Hydroxyphosphonate; Alcohol; Phenol; Silylation; Solvent-free
First Page Preview
Highly regio- and chemoselective silylation of diethyl α-hydroxyphosphonates, alcohols and phenols in the presence of solid TiCl3(OTf) as a catalyst with hexamethyldisilazane (HMDS) at room temperature in the absence of solvent
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 10, Issue 11, 10 June 2009, Pages 1547–1550
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis