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Ionic liquid as catalyst in the synthesis of N-alkyl trifluoromethyl pyrazoles

Paper ID Volume ID Publish Year Pages File Format Full-Text
51324 46839 2009 4 PDF Available
Title
Ionic liquid as catalyst in the synthesis of N-alkyl trifluoromethyl pyrazoles
Abstract

The efficacy of ionic liquids was evaluated in the N-alkylation reaction of 3,5-dimethyl- and 5-trifluoromethyl-3-methyl-1H-pyrazoles, from the reaction of N–H pyrazoles with alkyl halides (R1–X, where R1 = Bu, octyl, allyl, benzyl, –CH2CH2CONEt2, –CH2C(O)Ph, CH2CH2C(O)Ph and X = Cl, Br, I). Novel trifluoromethylated pyrazoles are among the compounds obtained. The reaction was chemoselective for trifluoromethylpyrazoles and 1-alkyl-3-trifluoromethyl-5-methyl-1H-pyrazoles were preferentially formed. The reaction time and yields were investigated and this method showed shorter reaction times and better yields in comparison with the reaction performed in molecular solvents.

Keywords
Ionic liquids; Alkylations reactions; Enones; Catalysis; Trifluoromethylpyrazoles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 10, Issue 8, 30 March 2009, Pages 1153–1156
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
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Price was $35.95
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100% Money Back Guarantee
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