fulltext.study @t Gmail

Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system

Paper ID Volume ID Publish Year Pages File Format Full-Text
51356 46840 2010 6 PDF Available
Title
Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system
Abstract

A study on the hydrogenation of ethyl pyruvate, methyl benzoylformate and 2,2,2-trifluoroacetophenone over Pt–cinchona alkaloid chiral catalysts and over the “unmodified” catalysts resulted after a cleaning step at 323 K of the chirally modified surfaces in continuous-flow fixed-bed reactor system is presented. According to these investigations the sense of the residual ee observed in the reactions carried out in the absence of modifiers over the catalysts rinsed after the chiral hydrogenations was influenced by the solvent and the structure of the activated ketone, pointing on the effect of these parameters on the structure of the adsorbed intermediate complexes and implicitly on the chiral induction.

Graphical AbstractFigure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights► Cinchona alkaloid modified Pt/Al2O3 was rinsed with solvent at 323 K. ► The sense of the residual ee was dependent on the solvent and substrate structure. ► Different activated ketones follow different routes during hydrogenation. ► The route followed is affected by the structure of the intermediate complexes.

Keywords
Asymmetric hydrogenation; Platinum; Cinchona alkaloids; Activated ketones; Flow reactor; Reversal of ee
First Page Preview
Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 12, Issue 1, 25 October 2010, Pages 14–19
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us