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Photocatalytic and AC magnetic-field induced enhanced cytotoxicity of Fe3O4–TiO2 core-shell nanocomposites against HeLa cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
51558 46847 2011 6 PDF Available
Title
Photocatalytic and AC magnetic-field induced enhanced cytotoxicity of Fe3O4–TiO2 core-shell nanocomposites against HeLa cells
Abstract

Fe3O4–TiO2 core-shell nanocomposites were successfully prepared and characterized by FE-SEM, XRD, UV–vis absorbance spectra, and EDX. The FE-SEM and EDX studies revealed core-shell structure with a particle size of ca. 40–50 nm. We adopted HeLa cells as a model to investigate the thermal-photocatalytic cell killing efficiency of Fe3O4–TiO2 using 150 μg/mL dose content for 10 min exposure time. We found neither only AC magnetic-field induction nor only photoirradiation condition could kill the cancer cells up to satisfactory level using Fe3O4–TiO2 nanocomposites. Finally, the results revealed that almost 100% cancer cells were destructed by Fe3O4–TiO2 nanocomposites whereas for bare Fe3O4 and bare TiO2, 90% and 56% cancer cells were killed, respectively, under combined AC (alternating current) magnetic-field induction and UV–vis photoirradiated conditions.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Fe3O4–TiO2 core-shell nanocomposites were successfully prepared. ► We noticed the core-shell structure with a particle size of ca. 40–50 nm. ► Thermal-photocatalytic cancer cell killing efficiency was investigated. ► Combined AC magnetic-field induction and photoirradiation conditions were used. ► Significant enhanced cytotoxicity was found under combined conditions.

Keywords
Cancer cells; Nanocomposites; AC magnetic-field; Photoirradiation; Hyperthermia
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Photocatalytic and AC magnetic-field induced enhanced cytotoxicity of Fe3O4–TiO2 core-shell nanocomposites against HeLa cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 16, Issue 1, 30 November 2011, Pages 39–44
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us