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Polymeric drug carriers—Control of the daily dose and therapy duration

Paper ID Volume ID Publish Year Pages File Format Full-Text
5161 344 2015 6 PDF Available
Title
Polymeric drug carriers—Control of the daily dose and therapy duration
Abstract

This study evaluates the mass release of cyanocobalamin with various drug carriers. Monolithic structures with a liquid core covering a thick (>150 μm) porous, polymer membrane are recommended. Membrane pore size should ensure easy diffusion of the drug molecules. The selection of the carrier's parameters to fit a required daily dose and therapy duration must consider the following criteria: 1′ the determination of its size (geometric surface); 2′ the number of carriers, if more than one is necessary; 3′ the thickness of membrane covering the carrier; and 4′ the mass of the loading drug.An algorithm to select these conjugated parameters to achieve the therapeutic threshold and duration of the drug effect was expanded upon.A system to constantly deliver drugs over days/weeks/months can be maintained if the loaded mass of the drug significantly exceeds its solubility in the carrier's core.

Keywords
Drug reservoir; Diffusion; Controlled release; Membrane parameters; Algorithm
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biocybernetics and Biomedical Engineering - Volume 35, Issue 3, 2015, Pages 192–197
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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