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Ionic liquid promoted cyclocondensation reactions to the formation of isoxazoles, pyrazoles and pyrimidines

Paper ID Volume ID Publish Year Pages File Format Full-Text
51670 46849 2010 4 PDF Available
Title
Ionic liquid promoted cyclocondensation reactions to the formation of isoxazoles, pyrazoles and pyrimidines
Abstract

A simple one-pot procedure to obtain a series of five- and six-membered heterocycles, in three different ionic liquids ([BMIM][BF4], [BMIM][OH] and [HMIM][HSO4]) is described. The synthetic protocol involves the reaction between β-enamino ketone derived from 1,4-diacetylbenzene and hydroxylamine, hydrazines (R1NHNH2, where R1 = H, Ph, 4-O2N-Ph, 2,4-(O2N)2-Ph, C6F5, CO2Me, CONH2, CH2CH2OH, t-Bu) or amidines (R2C(NH)NH2, where R2 = NH2, Ph), furnishing bis-isoxazoles, bis-pyrazoles and bis-pyrimidines in good yields and short reaction times.

Keywords
Ionic liquid; Cyclocondensation reaction; Heterocycles; Catalysis
First Page Preview
Ionic liquid promoted cyclocondensation reactions to the formation of isoxazoles, pyrazoles and pyrimidines
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 11, Issue 5, 25 January 2010, Pages 476–479
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis