Evaluation of the biocompatibility of a hydroxyapatite-CaTiO3 coating in vivo
ObjectiveThis study was designed to evaluate the biocompatibility and osteointegrative activity of hydroxyapatite (HA)-CaTiO3, titanium substrate, traditional HA coating and CaTiO3 coating via an animal experiment.MethodFour types of screws (type 1: coated with HA; type 2: coated with CaTiO3; type 3: coated with HA-CaTiO3; type 4: untreated titanium screws) were implanted into femur bone of 48 New Zealand rabbits. Histological and mechanical investigations were employed at the end of 2, 4, 8 and 12 weeks to evaluate the material osteointegration.Results(1) All of the experimental rabbits were healthy during the experiment process. (2) Histological investigation showed fully regenerated and well integrated bone tissue surrounding the screws coated with HA, HA-CaTiO3 and CaTiO3. (3) Mechanical investigation showed that the bonding strength of HA-CaTiO3 coating was significantly higher than that of CaTiO3 coating or titanium materials without coating, but was lower than those coated with HA.ConclusionHA-CaTiO3 coating possesses similar admirable biocompatibility and osteointegration activity with HA coating, indicating a promising coating material for implants in orthopedics.
Journal: Biocybernetics and Biomedical Engineering - Volume 35, Issue 4, 2015, Pages 296–303