Hematopoietic stem cell based therapy of immunosuppressive viral infection—Numerical simulations
In the light of recent advantages in stem cell research and gene based therapies of viral infections, we present a numerical experiment referring to hematopoietic stem cell based therapy of immunosuppressive viral infection. We use a variation of basic mathematical model for impairment of help to simulate immune impairing infection. Next, we increase virus-specific CTL production (as in therapy) in different stages of infection. Obtained results are analyzed and compared with results from recent in vivo experiment.
Journal: Biocybernetics and Biomedical Engineering - Volume 34, Issue 2, 2014, Pages 125–131