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Hematopoietic stem cell based therapy of immunosuppressive viral infection—Numerical simulations

Paper ID Volume ID Publish Year Pages File Format Full-Text
5195 348 2014 7 PDF Available
Title
Hematopoietic stem cell based therapy of immunosuppressive viral infection—Numerical simulations
Abstract

In the light of recent advantages in stem cell research and gene based therapies of viral infections, we present a numerical experiment referring to hematopoietic stem cell based therapy of immunosuppressive viral infection. We use a variation of basic mathematical model for impairment of help to simulate immune impairing infection. Next, we increase virus-specific CTL production (as in therapy) in different stages of infection. Obtained results are analyzed and compared with results from recent in vivo experiment.

Keywords
Numerical modeling; Virus; Adaptive immune system; Cellular immunity; Immunosuppression; Hematopoietic stem cells (HSC)
First Page Preview
Hematopoietic stem cell based therapy of immunosuppressive viral infection—Numerical simulations
Publisher
Database: Elsevier - ScienceDirect
Journal: Biocybernetics and Biomedical Engineering - Volume 34, Issue 2, 2014, Pages 125–131
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering