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Application and evaluation of layered silicate–chitosan composites for site specific delivery of diclofenac

Paper ID Volume ID Publish Year Pages File Format Full-Text
5202 349 2015 8 PDF Available
Title
Application and evaluation of layered silicate–chitosan composites for site specific delivery of diclofenac
Abstract

The present study focuses on the in situ intercalation of anionic drug (diclofenac sodium, DS) and cationic polymer, Chitosan (CS) in montmorillonite (MMT) for drug release applications. The prepared DS/CS-MMT composites were further compounded with alginate (AL) to form beads to modify release response in gastric juice. The DS/CS-MMT composites were characterized by UV spectroscopy, XRD, FT-IR, TGA and DSC. Antibacterial assay of drug loaded composites was investigated and in vitro cell viability assay results point out the drug encapsulated in clay plates are less toxic to the cell than pristine drug. The in vitro release experiments revealed that the DS was released from DS/CS-MMT/AL in a controlled and pH dependent manner.

Keywords
Layered structures; Chitosan; Thermal analysis; Biomaterials; Controlled release
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Application and evaluation of layered silicate–chitosan composites for site specific delivery of diclofenac
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biocybernetics and Biomedical Engineering - Volume 35, Issue 2, 2015, Pages 120–127
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us