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Animal Models of Duchenne Muscular Dystrophy, with Special Reference to the mdx Mouse

Paper ID Volume ID Publish Year Pages File Format Full-Text
5205 350 2012 13 PDF Available
Title
Animal Models of Duchenne Muscular Dystrophy, with Special Reference to the mdx Mouse
Abstract

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease that affects approximately 1 in 3500 male births. We describe animal models of DMD with special reference to the mdx mouse. We also describe some of the standard operating procedures (SOPs) developed by the TREAT-NMD neuromuscular network (http://www.treat-nmd.eu/) for assessment of the mdx mouse, with a focus on techniques for assessing cardiac function that are used in our lab, including the cardiac conductance catheter. We have also recently developed cardiac MRI as a novel cardiac assessment technique for mouse models of muscular dystrophy. We describe how this technique can be used both in the assessment of ventricular function and in the investigation of the role of abnormal calcium influx in muscular dystrophy-associated cardiomyopathy.

Keywords
duchenne muscular dystrophy; mdx mouse; cardiomyopathy; animal models; MRI; cardiac catheter; standard operating procedures
First Page Preview
Animal Models of Duchenne Muscular Dystrophy, with Special Reference to the mdx Mouse
Publisher
Database: Elsevier - ScienceDirect
Journal: Biocybernetics and Biomedical Engineering - Volume 32, Issue 4, 2012, Pages 3–15
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering