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Sporadic Amyotrophic Lateral Sclerosis: Brief Pathogenic Review and a New Causal Hypothesis

Paper ID Volume ID Publish Year Pages File Format Full-Text
5206 350 2012 16 PDF Available
Title
Sporadic Amyotrophic Lateral Sclerosis: Brief Pathogenic Review and a New Causal Hypothesis
Abstract

This article summarizes the pathogenic mechanisms known to be responsible for sporadic amyotrophic lateral sclerosis, such as excitoxicity, endoplasmic reticulum stress, oxidative stress, proteins damage, inflammation, genes abnormalities and neuronal death; some clinical features of the disorder are discussed as well. Finally, it puts forward the hypothesis that astrocytes, rather than the motor neurons, may be the cells initially damaged by the action of a still unknown causal agent, being the neuronal death a consequence of that first insult. The article suggests that an emergent virus, perhaps a retro-virus, or a misfolded infectious protein might be the agent able to accomplish the task.

Keywords
amyotrophic lateral sclerosis; sporadic amyotrophic lateral sclerosis; SALS cause; SALS pathogenesis; motoneurons related astrocytes; motor neuron diseases
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biocybernetics and Biomedical Engineering - Volume 32, Issue 4, 2012, Pages 17–32
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
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Full-text PDF Download
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