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The synthesis of coumarin-3-carboxylic acids and 3-acetyl-coumarin derivatives using heteropolyacids as heterogeneous and recyclable catalysts

Paper ID Volume ID Publish Year Pages File Format Full-Text
52080 46864 2008 5 PDF Available
Title
The synthesis of coumarin-3-carboxylic acids and 3-acetyl-coumarin derivatives using heteropolyacids as heterogeneous and recyclable catalysts
Abstract

Coumarin-3-carboxylic acids and 3-acetyl-coumarins were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and 1-ethylacetoacetate or malonic acid after a 2 h reflux in ethanol in the presence of a catalytic amount of different heteropolyacids (HPAs). The less reactive 1-(2-hydroxy-phenyl)-ethanone was first reacted with alcoholic ammonia to form ketimines, which were then condensed with 1-ethylacetoacetate or malonic acid to generate 4-methyl coumarin-3-carboxylic acids and 4-methyl 3-acetyl-coumarins in moderate yields.

Keywords
Coumarin-3-carboxylic acids; 3-Acetyl-coumarins; Recyclable catalysts; Heteropolyacids
First Page Preview
The synthesis of coumarin-3-carboxylic acids and 3-acetyl-coumarin derivatives using heteropolyacids as heterogeneous and recyclable catalysts
Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 9, Issue 3, 1 March 2008, Pages 470–474
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis