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Inversion of stereochemistry in the asymmetric transfer hydrogenation of ketones performed in tap water and in open-vessel

Paper ID Volume ID Publish Year Pages File Format Full-Text
52224 46867 2008 6 PDF Available
Title
Inversion of stereochemistry in the asymmetric transfer hydrogenation of ketones performed in tap water and in open-vessel
Abstract

The readily available amino alcohol 7 was employed into the [RuCl2(p-cymene)]2-catalyzed asymmetric transfer hydrogenation (ATH) of prochiral ketones performed in tap water. For the first time, the reaction was conducted in open-vessel at room temperature, providing moderate to good conversions and enantioselectivities. In addition, we have run some experiments to study the relationship between the structure of the chiral ligand and the catalytic efficiency. Surprisingly, N-substitution of 7 could lead to the inversion of the configuration of the product under the same conditions.

Keywords
Amino alcohol; Asymmetric transfer hydrogenation; Tap water; Open-vessel; Inversion of the configuration
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Inversion of stereochemistry in the asymmetric transfer hydrogenation of ketones performed in tap water and in open-vessel
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Publisher
Database: Elsevier - ScienceDirect
Journal: Catalysis Communications - Volume 9, Issue 5, 20 March 2008, Pages 618–623
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Catalysis
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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